Interpenetrating Polymer Network (ipn) Microparticles an Advancement in Novel Drug Delivery System: a Review

DELIVERY SYSTEM: A REVIEW Prashant Singh*, S.K. Senthil Kumar, T.S.Keerthi, T. Tamizh Mani, Anil Getyala Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathinagara, Mandya, Karnataka – 571422,India Department of Pharmacognosy, Bharathi College of Pharmacy, Bharathinagara, Mandya, Karnataka – 571422,India Department of Industrial Pharmacy, JSS College of Pharmacy, Mysore, Karnataka – 570015,India ABSTRACT Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers which are biodegradable in nature and ideally having a particle size less than 200 μm. Interpenetrating polymer network (IPN) is regarded as one of the most useful novel biomaterial containing two polymers, each in network form. The excellent biocompatibility and safety due to its physical characteristics such as impart stability of the drug in the formulations, improves solubility of hydrophobic drugs, excellent swelling capacity and its biological characteristics, like biodegradability, impart bioavailability, drug targeting in a specific tissue. The potential applications of IPN as drug delivery systems specially for the controlled release drug delivery systems. This article aims to provide a comprehensive review of merits, features, methods of microencapsulation, mechanism of drug release from microspheres, classification and problems occurs with different IPN.